Zhang et al. (2019a) reported that regulating the NF-κB/MAPK signaling pathway can reduce pulmonary inflammation in rats. Carlsen et al. (2015) found that quercetin (MOL000098) can restore the high expression of PTGS2 caused by inflammation to normal levels. It has been shown that the expression of the inflammatory mediator PTGS2 was inhibited by crocetin (MOL001406) in an inflammation model. Crocetin exerted an anti-inflammatory effect and improved inflammatory symptoms by suppressing the activation of the MAPK signaling pathway (Hemshekhar et al., 2012). The gene discussed is NFKB1; the disease is inflammation.