These genes are mainly related to host immunity, oxidative stress, bacteria, and microorganisms and are covered by the TNF signaling pathway (IL6, TNF, CCL2, MMP9, CRP, IL1B, PTGS2, and EGFR), IL-17 signaling pathway (IL6, TNF, CCL2, MMP9, IL1B, PTGS2, and EGFR), and Chagas disease pathway (IL6, TNF, TLR4, CCL2, CRP, IL1B, and EGFR). The gene discussed is TLR4; the disease is Chagas disease.