The expression of CD39 and CD73 ectonucleotidases was initially described in tumor cells, regulatory T cells (Tregs), and myeloid-derived suppressor cells (MDSCs), where they enhance their immunosuppressive function through the production of adenosine (Kobie et al., 2006; Borsellino et al., 2007; Deaglio et al., 2007; Li et al., 2017). Here, ENTPD1 is linked to neoplasm.