APOE and atherosclerosis: Small interfering RNAs (siRNAs) targeting multiple endothelial adhesion molecules reduced atherosclerosis in Apoe–/– mice markedly (Sager et al., 2016a), while specific targeting of Mac-1 binding to CD40L by a peptide inhibitor (Wolf et al., 2011), or a blocking antibody (Wolf et al., 2018) prevented inflammatory leukocyte recruitment (Michel et al., 2017) in mice.