To characterize the gene expression pattern of the Asian MB cohorts, we performed RNA-seq for 63 MB tumors (Supplementary Table 2), including WNT (n = 6), SHH (n = 20), G3 (n = 14), G4 (n = 19) MBs and apparently normal brain controls (n = 4, marked as NB). This evidence concerns the gene SHH and Mobius syndrome.