Although a cohort of patients in the G3 subgroup shared similar gene expression patterns with G4 MB patients overall, G3 MBs were distinguished by signatures of photoreceptor cells (p = 1.7e-8), or of MAPK (p = 7.3e-4) and FOXO (p = 9.4e-4) signaling, while signatures for axon guidance (p = 5.2e-6), ECM glycoproteins (p = 5.0e-6), SMAD phosphorylation (p = 3.7e-2), and estrogen receptor signaling (p = 4.7e-2) were enriched in G4 MBs (Figure 2C). The gene discussed is ESR1; the disease is Mobius syndrome.