METTL3 and neoplasm: Gene Ontology of analysis in DEGs associated with biological process enrichment upon control and Mettl3 KO mice revealed that those genes were selectively enriched by the regulation of angiogenesis, ameboidal-type cell migration, regulation of vasculature development, and endothelial cell proliferation, which was likely involved in construction of tumor microenvironment and sustaining tumor metastasis (Figure 4B).