METTL3 and neoplasm: Methyltransferase-like 3 and 14 (Mettl3 and Mettl14) and their cofactors, Wilms tumor 1 associated protein (WTAP), VIRMA (KIAA1429), and RBM15 function as writers and form m6A methyltransferase complex (MTC), which catalyzes A (adenosine) to become m6A. Emerging insights into the role of m6A regulation in biological processes and pathogenesis of diseases has been uncovered in recent years, mainly including cell fate determination, embryonic development, and tumor progression (Roundtree et al., 2017; Frye et al., 2018).