El-Sayed et al. found that HG decreased CSE expression/activity, H2S, and serum adiponectin level and increased myocardial imidazoline I1 receptor expression, while moxonidine (imidazoline I1 receptor agonist) abolished the above effects of HG and improved the glycemic state; reversed myocardial hypertrophy, hypertension, and baroreflex dysfunction in streptozocin (STZ)-treated rats; and inhibited the expression of death associated protein kinase-3 (DAPK-3) to play cardiovascular protective effects in diabetic mice. Here, DAPK3 is linked to hypertensive disorder.