ERS and NLRP3 inflammasome crosstalk has been reported to play an important role in metabolic disorders (Ji et al., 2019), and H2S regulates the ERS/NLRP3 inflammasome in many diseases (Wang et al., 2020a,b), so whether H2S can regulate the ERS/NLRP3 inflammasome to improve diabetes deserves to be studied. This evidence concerns the gene NLRP3 and diabetes mellitus.