Besides, Schoonjans et al. have demonstrated that PDK inhibitor dichloroacetate (DCA) and GLS1 inhibitor Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl) ethyl sulfide (BPTES) affect tumor angiogenesis by lowering glycolysis and glutamate production, respectively, in HUVECs (Schoonjans et al., 2020). The gene discussed is GLS; the disease is neoplasm.