To evaluate the roles of four well-known succinylation regulators (CPT1A, KAT2A, SIRT5, and SIRT7), we utilized the TCGA pan-cancer dataset to analyze the expression patterns and prognostic prediction values in 10 relatively common tumors including ESCA, STAD, LUSC, LUAD, LIHC, KIRP, KIRC, COAD, BRCA, and BLCA. This evidence concerns the gene KAT2A and cancer.