By correlation analysis using the online ccRCC protein dataset (Figures 7E,F), analysis of our tissue specimens (Figure 9B) and preliminary validation in the ACHN cell line (Figure 9C), we confirmed that CPT1A and SIRT5 could up-regulate and down-regulate the expression of LRPPRC and EIF3B in ccRCC, respectively. This evidence concerns the gene SIRT5 and nonpapillary renal cell carcinoma.