PRKAA2 and neoplasm: Our study identified aberrantly expressed mRNAs and lncRNAs in endothelial cells, analyzed their biological functions and the signal pathways in tumor–endothelium interaction, and it verified significant upregulation of PRKAA2 mRNA and its targeted miRNA, miR-124-3p, which plays a key role in endothelial cells with tumor adhesion.