According to the changes of the expression status of differential molecules between the two networks, we identified the top 10 differential mRNAs (PRKAA2, NLGN4X, ST6GALNAC3, DGAT1, TRIB1, GRPR, and MLLT11) and lncRNAs (n339695, n378130, and n410438) in the tumor–endothelium interaction (Table 4). The gene discussed is PRKAA2; the disease is neoplasm.