The alterative KEGG pathways associated with the downregulated mRNAs in endothelial cells included the PI3K-Akt signaling pathway, acute myeloid leukemia, Staphylococcus aureus infection, Staphylococcus aureus infection, and complement and coagulation cascades (Figure 3B). Here, PIK3CG is linked to staphylococcus aureus infection.