Expression of the lncRNA Hoxb3os (homeobox B3 and homeobox B2, opposite strand) is significantly decreased in the renal tissues of patients with autosomal dominant polycystic kidney disease (ADPKD) and in a mouse model of ADPKD (Aboudehen et al., 2018). The gene discussed is HOXB3; the disease is autosomal dominant polycystic kidney disease.