OPA1 and diabetes mellitus: As shown in Figure 4, diabetes significantly increased the level of pro-fission protein Drp1 and suppressed the level of pro-fusion protein Opa1 in diabetic KCa3.1 wild-type mice (K+/+ DM) compared to non-diabetic control mice (K+/+ control) (P < 0.05, Figures 4A,C).