MAPT and epilepsy: Furthermore, although knockdown or knockout of tau proteins have been evidenced to significantly attenuate neuronal network hyperexcitability in the brain of mice with epilepsy (DeVos et al., 2013; Holth et al., 2013), whether and how the abnormal accumulation of hyperphosphorylated tau dysregulates neuronal firing activities thus to affect epileptic seizures in epilepsy still remain to be elucidated.