Hyperphosphorylation and intracellular accumulation of tau protein dysregulate microtubule assembly and aggravate the formation of neurofibrillary tangles, thus remodeling neuronal synapses and exacerbating cognitive decline in a collection of diseases named tauopathies, including Alzheimer disease (AD; Wang et al., 2014; Wang and Mandelkow, 2016; Yang and Wang, 2018). This evidence concerns the gene MAPT and Alzheimer disease.