Furthermore, although knockdown or knockout of tau proteins have been evidenced to significantly attenuate neuronal network hyperexcitability in the brain of mice with epilepsy (DeVos et al., 2013; Holth et al., 2013), whether and how the abnormal accumulation of hyperphosphorylated tau dysregulates neuronal firing activities thus to affect epileptic seizures in epilepsy still remain to be elucidated. Here, MAPT is linked to Seizure.