Moreover, as Y5R and NPY expression have been shown in other metastatic tumors, blocking this pathway may become an effective anti-metastatic therapy for malignancies other than NB (Kitlinska et al., 2005; Medeiros et al., 2011; Tilan et al., 2013; Ueda et al., 2013; Tjon-Kon-Fat et al., 2018; Dietrich et al., 2020). This evidence concerns the gene NPY and metastatic neoplasm.