HIF1A and non-small cell lung carcinoma: Followed by miR-199a-5p overexpression or inhibition in NSCLC cells, no obvious alteration was noted in STAT3 expression, whereas miR-199a-5p was observed to inactivate STAT3 phosphorylation; besides, it was demonstrated that HIF-1α overexpression activated the phosphorylation of STAT3, while STAT3 overexpression or HIF-1α overexpression further reduced miR-199a-5p expression in H1299 cells (Figures 6D–K).