FOXC2 and colorectal carcinoma: Multiple gene signatures, including NLRP3, CAF, JMDJ1C, FOXC1, and FOXC2, contribute to the carcinogenesis and metastasis of CRC (Cui et al., 2015; Chen et al., 2018; Liu et al., 2018; Paauwe et al., 2018; Deng et al., 2019).