This hypothesis is particularly intriguing in regard to influenza infection: although IL-37 is detectable in the humans and mice throughout influenza infection, exogenous administration of IL-37 only produced beneficial effects in infected mice late in infection, suggesting that IL-37 may be sequestered in some manner early in infection (Qi et al., 2019; Zhou et al., 2019). The gene discussed is IL37; the disease is influenza.