Berberine has also been shown to promote the interaction between retinoid X receptor alpha (RXRα) and nuclear β-catenin; this leads to the Casitas B-lineage lymphoma (c-Cbl)-mediated degradation of β-catenin, thereby inhibiting the proliferation of colon cancer cells (Ruan et al., 2017). This evidence concerns the gene RXRA and malignant colon neoplasm.