IFNG and tuberculosis: Interferon-gamma (IFN-γ) release assays (IGRAs), including T-SPOT.TB and QFT-G, display a higher sensitivity compared to the TST for specific detection of latent TB, pulmonary TB or extrapulmonary TB, based on the T-cell mediated IFN-γ release induced by specific M. tuberculosis antigens, including ESAT-6, CFP-10 and TB7.7.