Serum CA 19-9 > 37 U/ml and positive perineural invasion were significantly associated with poor survival in the intestinal-type ampullary tumors, whereas serum CEA > 5 μg/ml and tumor sizes > 2.5cm were significantly associated with poor survival in the pancreatobiliary-type ampullary tumors. The gene discussed is CEACAM5; the disease is neoplasm.