GRB2 and pachyonychia congenita: For example, in pancreatic cancer (PC), WTAP can promote chemo-resistance of PC cells to gemcitabine through stabilizing Fak mRNA and activating Fak signaling pathways, including Fak-Src-GRB2-Erk1/2 and Fak-PI3K-AKT pathways (18).