Resveratrol significantly reduced miR-196b/miR-1290 expression in the T-ALL (T-cell acute lymphoblastic leukemia) TTL-104 and B-ALL (B-cell acute lymphoblastic leukemia) SUP-B15 cell lines and upregulated the expression of IGFBP3. The gene discussed is IGFBP3; the disease is acute lymphoblastic leukemia.