An inverse correlation between vitamin D receptor expression and FOXM1 in pancreatic ductal carcinoma patients was observed by Li Z et al. Pharmacological activation of Vitamin D receptor (VDR) by vitamin D and its analog has led to the suppression of FOXM1 signaling as evidenced from the expression of its downstream targets such as cyclin D1, CMYC, SKP2, CD44 and c-MET (61). This evidence concerns the gene FOXM1 and pancreatic ductal adenocarcinoma.