A combination of estrogen receptor (ER), progesterone receptor (PR), vimentin, and CD10 negativity along with carcinoembryonic antigen (CEA), diffuse p16, CD34, and HPV positivity suggests cervical adenocarcinoma, while a combination of ER, PR, vimentin, diffuse p16, and CD10 positivity along with CEA, CD34, and HPV negativity suggests uterine adenocarcinoma (17, 22). The gene discussed is PGR; the disease is cervical adenocarcinoma.