According to the results depicted in Figures 3A–C, only the combination of PTX + CIS induced PARP-1 cleavage in SiHaP cells, while in SiHaCIS-R, PARP-1 cleavage was induced by the treatment with PTX or CIS alone and the combination of both (PTX + CIS). This evidence concerns the gene PARP1 and in situ carcinoma.