In the present study the 13 IRGs that were strongly associated with CRC prognosis—CXCL1, F2RL1, LTB4R, GPR44, ANGPTL5, BMP5, RETNLB, MC1R, PPARGC1A, PRKDC, CEBPB, SYP, and GAB1—were used in the classifier investigation. The gene discussed is RETNLB; the disease is colorectal carcinoma.