Interestingly, key regulators of cell cycle and apoptosis were downregulated in MM-MSCs, including cyclin dependent kinase inhibitor 2C (CDKN2C), a cell cycle regulator that controls G1 progression, and programmed cell death 4 (PDCD4), which regulates proliferation by inducing cell cycle arrest at G1 (39). This evidence concerns the gene PDCD4 and Miyoshi myopathy.