Exposure to 5TGM1 soluble factors CM (Supplementary Figure 5D), or with transwell indirect co-culture (Supplementary Figure 5E), also had no significant effects on in the secretion of over 40 cytokines, (including IL-6, CXCL1, and CXCL2), assessed via cytokine array; suggesting a differential effect of either myeloma cell line, or between species. This evidence concerns the gene CXCL1 and plasma cell myeloma.