Adipocyte-derived factors such as MCP-1/CCL2 and SDF1α/CXCL12 are chemotactic factors for myeloma cells (8, 15), while other adipokines promote myeloma proliferation (e.g., leptin/LEP) (18) and resistance to chemotherapies (e.g., leptin/LEP, adipsin/CFD) (9, 23). The gene discussed is LEP; the disease is plasma cell myeloma.