Moreover, COL1A1 was previously found to be regulated by miR-98 in hypertrophic scarring (32) and muscular dystrophies (33); overexpression of miR-98 could increase cell apoptosis and enhance sensitivity to cisplatin in lung adenocarcinoma (34); and low miR-98 expression was correlated with temozolomide resistance of glioma (35). Here, COL1A1 is linked to central nervous system cancer.