SIK1 and colorectal carcinoma: As shown in Figures 3A–D and Supplemental Figure S2A, there was no significant difference in OS curves between the DDR Mut and WT groups in the TCGA CRC cohort (P=0.460), the TCGA CRC III/V cohort (P=0.860) or the MSK non-ICI CRCs (P=0.630).