KEGG enrichment analyses revealed that miR-1539 was involved in several cancer signaling pathways, including, phosphatidylinositol 3-kinase (PI3K), mitogen activated protein kinase (MAPK), the janus kinase (JAK)-signal transducer and activator of transcription (STAT), Ras, receptor-associated protein-1 (Rap-1), adenosine 5’-monophosphate activated protein kinase (AMPK), hypoxia inducible factor (HIF) and p53 (Figure 6D). Here, TP53 is linked to cancer.