IL1B and preeclampsia: IL-1β [24, 79, 103, 110, 136], IL-4 [103, 104, 106, 107], and IL-13 [104, 132] do not appear to significantly contribute to the pathogenesis of preeclampsia as most research examined in this review indicated no difference in these cytokine concentrations between preeclampsia and healthy pregnancy in the third trimester.