The mean concentrations for leptin and CRP were higher in participants with overweight/obesity compared to participants who were underweight/normal weight (7.9 ± 5.9 ng/ml vs. 3.5 ± 4.7 ng/ml and 0.33 ± 0.6 μg/ml vs. 0.14 ± 0.4 μg/ml, respectively). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.