MLXIPL and steatosis: Previous studies showed a strong association between steatosis development and diets, gut microbiota, genetic background, and regulation of de novo lipogenesis via lipogenic transcription factors including sterol regulatory binding protein-1c (SREBP1c) that were involved in mediating the effect of insulin on hepatic gene expression, and carbohydrate-responsive element-binding protein (chREBP) that were regulated by glucose for gene transcription(14-16).