VDAC1 and breast cancer: Table 2 showed the result of IHC staining of VDAC1 protein. Of 219 BC samples, 162 (73.97%) showed high expression of VDAC1 protein, and 57 (26.03%) showed low expression. In benign breast lesions, 55 (55%) showed high expression of VDAC1 protein, and 45 (45%) showed low expression. The expression of VDAC1 was significantly higher in BC tissues (χ2 = 11.361, P = 0.001) as determined by chi-square test.