The expression of VDAC1 protein in breast cancer solid tumors was significantly higher than that in benign breast lesions, and high expression of VDAC1 protein correlated with advanced TNM stage, higher histological grade, recurrence, lymph node metastasis, and HER2 gene amplification, thereby suggesting that high VDAC1 expression may play a role in promoting tumorigenesis and progression of BC. The gene discussed is VDAC1; the disease is breast carcinoma.