Several posttranslational modulation (PTM) patterns of MnSOD have been reported, such as nitration [37], acetylation [38], and ubiquitination [39], among which acetylation of MnSOD is one of the main drivers of its enzyme activity which has attracted widespread attention and been reported in various kinds of diseases, such as breast cancer [40] and cardiac diseases [41]. Here, SOD2 is linked to breast cancer.