Although many studies have confirmed the correlation between inflammation and oxidative stress and the severity and prognosis of HF, except vitamin C, coenzyme Q10, and IL-1 antagonist anakinra, most of the clinical trials of anti-inflammatory and antioxidant therapy have been proved unsuccessful, indicating that we still have many unknowns about the mechanism of inflammation and oxidative stress in HF. This evidence concerns the gene IL1B and hydrops fetalis.