By contrast, antagonistic HMGB1 box A, miR-129-5p, and the natural product HMGB1 inhibitor glycyrrhizic acid reduce infarct size and tissue damage of the heart; inhibit oxidative stress and inflammatory response; and prevent pressure overload-induced cardiac hypertrophy, heart fibrosis, and failure [144–147]. Here, HMGB1 is linked to cardiac hypertrophy.