PADI4 and myocardial ischemia: In a mouse myocardial ischemia model, GSK484, a PAD4 inhibitor, reduces infarct size and cardiomyocyte apoptosis, promotes the improvement of cardiac function, ameliorates cardiac neutrophil infiltration and NET formation, depresses PAD4 expression and cit-H3 level, and inhibits secretion of inflammatory cytokines [57].