In addition to the Kubota group, which used HMGB1 transgenic mice to show that cardiac nuclear HMGB1 exerts protective effects on myocardial infarction, cardiac hypertrophy, and HF [138–140], many studies have shown that HMGB1 is an independent predictor of death in HF [141–143]. This evidence concerns the gene HMGB1 and cardiac hypertrophy.