Another study found that Tongxinluo, a medicine for treating coronary heart disease, was involved in activating Parkin and reducing the activity of the ubiquitin system to attenuate myocardial I/R injury [57], although few studies have reported which particular or active ingredients of the Tongxinluo capsule may play a regulatory role in the PINK/Parkin pathway [58, 59]. This evidence concerns the gene PRKN and coronary artery disorder.