The AUCs of GOLPH3, CEA, and CA19-9 in GC patients were 0.881 (95% CI: 0.824-0.939, P < 0.001), 0.858 (95% CI: 0.796-0.919, P < 0.001), and 0.674 (95% CI: 0.587-0.760, P < 0.01), respectively. Here, GOLPH3 is linked to gastric cancer.