The AUCs of GOLPH3, CEA, and CA19-9 in CRC were 0.888 (95% CI: 0.840-0.935, P < 0.001), 0.857 (95% CI: 0.790-0.923, P < 0.001), and 0.700 (95% CI: 0.623-0.778, P < 0.001), respectively. The gene discussed is CEACAM5; the disease is colorectal carcinoma.