In addition, serum concentrations of GOLPH3 in patients with tumor size more than 5 cm, deeper infiltration, poor differentiation, lymph node metastasis, and distant metastasis were significantly higher than those in patients with tumors of less than 5 cm, shallower infiltration, better differentiation, no lymph node metastasis, and no distant metastasis (P < 0.05). This evidence concerns the gene GOLPH3 and neoplasm.