EGFR and glioblastoma: Then another phase II study which was a single-arm on 32 heavily pretreated, recurrent GBM patients evaluated combining erlotinib with sirolimus and found that no radiological response was found and PFS-6 was only 3.1% [30], and also, unfortunately, no correlation between OS and EGFRvIII, pEGFR and EGFR amplification.