EGFR and glioblastoma: Human EGFR (EGFR; HER-1) is over-expressed in 40%–60% of primary GBM tumours and mostly occurs in the classical subtype (Figure 1) [15], but EGFR mutation which leads to EGFRvIII expression (Figure 2) present in 20%–30% of primary GBM [15].