In summary, compared with WM used alone, LDXGD used alone or combined with WM had a higher cure rate (RR = 1.56, 95% CI (1.35, 1.81), P < 0.00001) and total effective rate (RR = 1.26, 95% CI (1.19, 1.34), P < 0.00001) in treating eczema, and lower levels of IL-6 (SMD = −1.61, 95% CI (−1.91, −1.30), P < 0.00001), IL-8 (SMD = −1.68, 95% CI (−1.99, −1.38), P < 0.00001), and TNF-α (SMD = −1.68, 95% CI (−1.98, −1.37), P < 0.00001) after treatment. This evidence concerns the gene CXCL8 and Eczematoid dermatitis.