Besides, YKL-40 is an independent predictor or a prognostic biomarker of many cardiac events: coronary artery disease (CAD), number of diseased vessels, acute myocardial infarction (MI), angiographic lesion progression and cardiovascular mortality even in patients with stable CAD, fate of heart failure patients and overall mortality; also, statin treatment reduced serum YKL-40 level in CAD patients (13, 22, 25, 29-31). The gene discussed is CHI3L1; the disease is heart failure.