Consumption of high doses of polyphenols present in tea are associated with elevated homocysteine levels in plasma and aqueous humor.12 Homocysteine augments the expression of elastin and causes structural changes promoting its aggregation, thereby contributing to development of PEX.20 It also causes vascular damage and oxidative stress, thereby contributing to the development of exfoliation glaucoma and other systemic disorders.21 This evidence concerns the gene ELN and exfoliation syndrome.