RARRES2 and osteoporosis: However, contradictory data is available regarding chemerin effects on bone homeostasis as a recently conducted in vitro research concluded that treatment with chemerin prevents bone loss by inhibiting the formation and activity of osteoclast in breast cancer cells invading the bone tissue.19 Similarly, another study showed that chemerin can be used therapeutically to target osteoporosis due to its bone formation activity and inhibition of bone resorption.20