RARRES2 and osteoporosis: It is believed that Chemerin is not only involved in controlling the growth of adipocytes and the metabolism of glucose, but it also modifies metabolic functions in mature adipocytes.2 Besides, experimental evidence suggested that chemerin and its CMKLR1 receptor can play an important role in osteoblastogenesis, bone mineralization, and osteoclastogenesis inhibition.3 Few studies have explored the associations in humans between circulating levels of chemerin and bone mineral density (BMD) or osteoporosis.