NPPB and cardiomyopathy: ProBNP is mainly synthesized and secreted by cardiac myocytes in response to myocardial wall stretch.5 ProBNP splits into BNP (32 amino acid) and N-Terminal proBNP (76 amino acid).6,7 Frequent ventricular ectopic beats have a high risk of developing dilated type reversible cardiomyopathy.8 A high PVCs burden is an important predisposing factor for developing cardiomyopathy but not every patient with high burden develop cardiomyopathy.