In addition to CD8+ T cell infiltration at the edge of vitiligo skin lesions, innate immune cells such as natural killer (NK) cells, inflammatory dendritic cells (DCs), and macrophages are also observed, indicating that the innate immune response is involved in the occurrence and development of vitiligo, Except for CD8+ T cells, the role of these cells in the pathogenesis of vitiligo is still unclear. The gene discussed is CD8A; the disease is vitiligo.