Supplementary Figure 2A shows the heat map correlation of epigenetic candidate gene expression in COVID-19 lung with AZA treated lung epithelial cell lines and immune-related cell line. We also examined the mRNA levels for different DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B) in SARS-COV-2 infected epithelial cells (NHBE and A549). Interestingly, all three DNA methyltransferases were significantly downregulated following infection (Supplementary Figure 2B). The gene discussed is DNMT3A; the disease is infection.