DNMT1 and acute myeloid leukemia: Moreover, Wang et al. (2019) found similar results of those previously reported by Lujambio et al. (2008) and Sengupta et al. (2018), in an acute myeloid leukemia cell line, i.e., the increase in miR-148a decreases the expression of DNMT1 (both mRNA and protein), which may impact the DNA methylation profile, suggesting that lower DNMT1 activity is related to a decrease in the methylation levels of promoter region’s CpG islands of miR-148a and, consequently, increases miR-148a expression, creating a negative feedback system.