Functional prediction of miRNAs revealed that compared with the control group, 59 relevant pathways (such as PI3K-Akt signaling pathway, FoxO signaling pathway, fluid shear stress and atherosclerosis, and MAPK signaling pathway) and 1,050 BP functions (such as cellular response to steroid hormone stimulus, ERK1 and ERK2 cascade, anatomical structure homeostasis, and smooth muscle cell proliferation) were obtained in the atherosclerotic plaque group. Here, MAPK1 is linked to atherosclerosis.