NR3C2 and Hypertension: Differential expression analysis of MYRIP knockdowns compared to the control in IPA also showed changes in aldosterone signaling that included an increase in expression of the aldosterone mineral corticoid receptor, NR3C2. The mineral corticoid receptor is widely expressed in the cardiovascular system and is a major determinant of endothelial function, smooth muscle tone, vascular remodeling, and hypertension (Belden et al., 2017).