Considering that an epilepsy model induced by PTZ is usually used to observe changes of excitatory/inhibitory regulatory molecules during the period of acute convulsions, this study successfully used the model to confirm increased DTNBP1 expression in the PTZ model, which indicates that the model can be used for disclosing potential mechanisms of DTNBP1 in future experiments. This evidence concerns the gene DTNBP1 and epilepsy.