BDNF and schizophrenia: The DTNBP1 gene encodes dystrobrevin binding protein 1, which participates in organelle biogenesis, and recent evidence indicates that it plays key roles in brain development, neuronal excitability, and schizophrenia-related pathologies (Chen et al., 2008; Saggu et al., 2013; Wang et al., 2017; Konopaske et al., 2018; Mohamed et al., 2018), i.e., decreased expression of DTNBP1 was observed to reduce exocytosis of brain-derived neurotrophic factor (BDNF) from cortical excitatory neurons.