In the training cohort, according to the results of univariate logistic regression analysis, the eight-miRNA signature, and five clinical risk factors (age at diagnosis, tumor size, grade, TNM stage, and HER2 status) with values of p less than 0.1 were included in multivariate regression analysis for assessing the independent risk factors for lung metastasis (Table 2). The gene discussed is ERBB2; the disease is neoplasm.